Tadalafil

Tadalafil is a medication which is sold under the brand name Cialis among others, used to treat erectile dysfunction. There are additional uses, and we will explain these in more detail shortly. The medication has a similar mechanism of action to other erectile dysfunction medications, but this treatment has a much longer duration of action.

It was developed in the 90s and approved for use in the US by the Food and Drug Administration (FDA) in 2003. It has been approved by the European Medicines Agency (EMA) and is available as a generic medication. Despite being an Rx-only medication, you can buy the treatment online without the need for a prescription, from our online pharmacy.

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What is Tadalafil Used For?

In a medical context, what is tadalafil used for? These tablets have a range of uses and we are going to explain the most common disorders in more detail now. Erectile dysfunction, also known as impotence, is defined as difficulty getting an erection, and difficulty keeping an erection, despite the desire to have sex. The tablets are licensed to treat erectile dysfunction, and this is the most common use for the medication. If you find it difficult to get an erection or struggle to keep it despite being in the mood, then you may be suffering from erectile dysfunction.

Some people will only experience mild or infrequent symptoms, whereas others will suffer from more severe symptoms. Erectile dysfunction more commonly affects men over the age of 40, however it can affect younger men as well. This medication will not be effective if your impotence is caused by a low sex drive. Some common causes of erectile dysfunction include the following:

  • Hormonal problems
  • Hypertension
  • Arteriosclerosis or atherosclerosis
  • Depression
  • Anxiety

Treatment options will depend on the cause, but medications like this treatment are commonly used as they are effective with low risk. Most men will find they cannot achieve an erection at some point in their life, which is normal and nothing to be concerned about, however, tadalafil benefits these people with an easy solution.

In cases where erectile dysfunction is a secondary condition due to a psychological disorder, therapy such as cognitive behavioural therapy (CBT) may be recommended. Many people choose to buy Flibanserin and practice psychological therapeutic techniques alongside each other for best results.

what is tadalafil used for besides treating erectile dysfunction? The medicine is also used to treat pulmonary arterial hypertension, a disease which is caused by the thickening of small arteries which carry blood to the lungs. When the arteries thicken and become stiffer, pressure builds up as there is less space for the blood to pass through and less elasticity for expansion. This build-up of pressure causes damage to the right side of the heart, which left untreated will eventually lead to heart failure.

Other types of hypertension can also lead to erectile dysfunction as they involve the cardiovascular system. The medication allows blood to flow more freely throughout the body by reducing blood pressure and dilating blood vessels. We will explain the mechanism of action in more detail now.

How Does Tadalafil Work?

what is tadalafil good for and how does it work? In response to sexual stimulation, nitric oxide (NO) is released from endothelial cells and nerve terminals, which stimulates the synthesis of cyclic guanosine monophosphate (cGMP). The secretion of cGMP causes the arteries in the penis to relax, increasing blood flow to the corpus cavernosum, (sponge-like region) where most of the blood is located during an erection.

The tablets work by inhibiting phosphodiesterase type 5 (PDE-5), which is an enzyme that breaks down cyclic guanosine monophosphate (cGMP), meaning blood can continue to flow easily to the tissues in the penis. This enhanced blood flow is how an erection is achieved and sustained, so when vessels are constricted in any way there will be an inadequate flow of blood.

If blood cannot physically enter the penis an erection will not be possible. That being said, you do have to have some level of desire for the medication to work, it will not automatically give you an erection. Additionally, there are some underlying conditions which means erectile dysfunction will not be treated as effectively with this kind of medication, such as Peyronie's disease.

This is a condition defined by the presence of scar tissue which reduces elasticity in the affected areas. The penis curves in the direction of the scar tissue when erect, which can result in pain and discomfort, causing erectile dysfunction, in which case other treatments such as pain relief may be necessary in addition.

How Long Does Tadalafil Last?

The medicine is rapidly absorbed into the bloodstream via the gastrointestinal tract and has a quick onset of action of around 30 minutes. The bioavailability varies from person to person, but it has an average protein binding of 94%. The duration of action lasts for up to 36 hours, which is why it has the nickname 'the weekend pill'. The elimination half-life is 17.5 hours, so after 36 hours there will be 25% of the medication left in your system.

As the duration of action is so much longer than other similar medications such as Viagra, which last for around 4 hours, this is one of the major tadalafil benefits making it an attractive option. This is particularly useful if being spontaneous is an important part of your sex life and you don't like having to plan it. Once you have taken it, you can have sex as many times as you like until the medication is no longer in your system.

Tadalafil Dosage Instructions

The 10 mg pill is the dose prescribed for most men with erectile dysfunction, but lower or higher tadalafil dosage may be indicated if necessary. The 20 mg dosage is the highest dose used for erectile dysfunction and this is indicated if the usual dose is not strong enough. It is always beneficial to take the lowest therapeutic dose possible to avoid the risk of any potential adverse effects. It is also available in strengths of 2.5 mg and 5 mg which are used for men who are more sensitive to medications or where contraindications exist, making higher doses more dangerous.

Regardless of the strength of your tadalafil dosage, you should take it at least 30 minutes before you need it to work so that it can be adequately absorbed and in your system, so you are free to have sex without needing to worry about whether it is going to work or not. You will need to be aroused for the medication to work as it is not an aphrodisiac, meaning it will not automatically result in an erection. If you were intending to have sex and something happens to interrupt it, there is no need to worry - you won't just be stuck with an erection!

If you are struggling with low libido, or low sex drive, then this is a different issue which would need to be addressed and you may need to have psychological treatment alongside physiological methods. Psychological approaches include talking therapies such as cognitive behavioural therapy (CBT) and this can be done either on your own or with your partner as couples' therapy. If you are taking it for pulmonary hypertension The 20 mg or 40 mg pills are the usual strengths prescribed unless lower doses are recommended due to factors such as liver or kidney disease.

This treatment and other similar medications with the same mechanism of action (PDE-5 inhibitors) target the functioning of the cardiovascular system, so there are some conditions which will be more effectively treated than others. If you are suffering from erectile dysfunction as a secondary condition, primary conditions which are not cardiovascular in nature may not respond quite as well. This is not a significant issue for most people as most reasons for erectile dysfunction are due to constricted blood vessels or issues with blood pressure.

Even though the targeted system for the medication is the cardiovascular system, achieving and maintaining an erection, whether naturally occurring or medication induced, electrical signals need to be transmitted throughout the central and peripheral nervous system. This means that primary conditions that affect nerves, such as multiple sclerosis (MS) will be harder to treat. One additional point to consider is that as the effects last for longer than 24 hours, it is advisable not to take the medication every day. Users are advised to observe their tadalafil dosage.

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Tadalafil Side Effects

Unfortunately, like all medications, the treatment has the potential to cause side effects, however tadalafil side effects are uncommon and for those that experience them they are usually mild and go away on their own. You do not need to stop taking it if you experience mild side effects unless they particularly bother you. Some of the more common Tadalafil side effects include:

  • Headaches
  • Muscular aches and pains
  • Nausea
  • Facial flushing

Drinking plenty of water will keep your blood pressure from dropping too low and should mitigate against most side effects. Serious side effects are very uncommon, but before you buy, you should be aware of any that may occur. One of the more serious tadalafil side effects is a sustained erection lasting for 4 hours or more, called priapism. If you experience this, you should seek medical attention by going to a walk in centre, sexual health clinic, or to the hospital. Other serious side effects to be aware of include the following:

  • Sudden change in eyesight
  • Sudden change in hearing
  • Chest pain
  • Seizures

You should stop taking the medication if you experience any of the above side effects and seek medical attention. Just to reiterate, these serious side effects are rare so they shouldn't be anything to worry about.

How Safe Is Tadalafil?

Tadalafil tablets are safe for most people, but there are some contraindications you should be aware of. You should not take this medication if you are taking nitrate-based medications this could cause your blood pressure to drop to dangerously low levels. If you have any of the following conditions, you should speak to your doctor before taking tadalafil tablets:

  • If you have had an allergic reaction to the ingredients before
  • You have heart problems or have suffered a heart attack before
  • You have serious kidney or liver problems
  • You have blood pressure problems
  • You have sickle cell anaemia or leukaemia

Tadalafil vs Viagra

does tadalafil work in a medical context better than Viagra? Well, they are very similar medications and they both work by inhibiting the PDE-5 enzyme which relaxes smooth muscle thereby dilating blood vessels and increasing blood flow to the penis. Although they have very similar mechanisms of action, the main differences are the price and the elimination half-life.

As Viagra is the most well-known it is the most expensive, and we believe in providing affordable medication. The elimination half-life is substantially longer than that of Viagra, being 17.5 and 4 hours respectively, which means you do not have to plan when you want to have sex, which is one of the tadalafil benefits.

Before You Buy Tadalafil Online

Before you buy tadalafil tablets there are some things worth considering. If your erectile dysfunction is due to an underlying health condition, it could be possible to cure the disorder by treating the primary condition. If you have cardiovascular issues, diabetes, or a high BMI, for example, then an exercise routine and healthy diet could really help. This will help with your cardiovascular health such as improving blood flow.

Additionally, exercising and healthy eating releases natural endorphins which can improve your mood and increase motivation. Getting in shape can help with self-esteem which can help with anxiety and depression. Many people opt to buy Tadalafil to use alongside alternative measures for a holistic approach, which is considered the most effective way to manage erectile dysfunction. Whether you are a regular user or still among those wondering 'does tadalafil work?', you can address your needs with us.

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Buy Tadalafil Online

This treatment is usually an Rx-only medication, however if you are struggling to get a prescription, you can buy Tadalafil online from our pharmacy. Not everyone feels comfortable going to their doctor to talk about erectile dysfunction, which is completely understandable. The decision about treatment options should not be down to another person and we advocate being able to have the freedom to choose the treatment that works best for you.

You can buy Tadalafil online from our site at affordable prices with quick and discreet delivery. Visit onlinekamagra.com for our full range of products.

Dr. Reginald Smythe (MChE)
Reviewed by:

Dr. Reginald Smythe (MChE)

Dr Smythe has been in the medical industry his whole adult life. As a child, he was a very quiet boy who enjoyed reading and climbing trees. As a young adult, he developed a passion for chemistry and his curiosity even had him creating his own fireworks.

Checked: 26th March 2023
Review Due: March 2024

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